Abstract
THE ROLE OF SOME ANTIOXIDANTS ON ABSORPTION, DISTRIBUTION AND ELIMINATION OF LEAD AND IRON: AN IN -VIVO STUDY.

Mahmud Abdullahi Ginya, Mustapha Balarabe Idris, Umar Abdullahi Zakariyya*, Deepha Singh, Hafeez Muhammad Yakasai1 and Nura Sani

ABSTRACT

Metals are an integral part of many structural and functional components in living cells, the critical role of metals in physiological and pathological processes can never be underestimated. The present work is aimed at an in-vivo study for the role of some antioxidants on absorption, distribution and elimination of Lead and Iron. Forty healthy albino rats weighing 130-140g were used in the current study. They were divided into Five (5) groups and standard method of sample collection, preparation, digestion and analysis were followed. There were substantial reduction in the level of iron and lead concentration in all the tissues after supplementation. Among the supplements, ascorbic acid was found to be more effective in absorption, distribution and elimination of the metals.

Keywords: Antioxidant, elimination, supplement, toxicity.


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