Abstract
METFORMIN HCL LIPOSOMAL DRUG DELIVERY SYSTEM: FORMULATION AND IN-VITRO EVALUATION

K. Janaki*, P. Deepika, P. Venkatesh, D. Varun and S. K. Godasu

ABSTRACT

The medicine launch from Liposomes depends upon many aspects consisting of the structure of Liposomes, the
kind of medicine encapsulated and nature of the cell. Once it is released a medicine that generally goes across the
membrane of a cell will certainly enter the cell, various other medicines will not go into. Metformin HCl is a short
biological half-life. This research study targeted at Formula As well as In-Vitro Assessment of Liposomal Drug
Shipment System of Metformin HCl in order to boost its bioavailability. In examination study the result of the
differing make-up of lipids on the residential or commercial properties such as encapsulation efficiency, fragment
size as well as medication release were researched. Stage change research was executed to validate the total
interaction of Metformin HCl with bilayer structure of liposome. Moreover, the launch of the drug was likewise
modified as well as crossed a duration of 8 h in all solutions. F1 became one of the most acceptable formula in so
far as its residential or commercial properties were concerned. Additionally, release of the medicine from the most
sufficient formula (F1) was assessed via dialysis membrane layer to get the idea of medication launch.

Keywords: Liposomes, Metformin HCl, Bioavailability.


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