Abstract
PHYTOCHEMICAL DETERMINATION AND ANTI-CANCER ACTIVITY OF CALOTROPIS GIGANTEA

B. Premkumar*, K. Anagha Nandan, V. Adarsh, K. Abishek, V. Arun Kumar and Asif Muhammed

ABSTRACT

The present study was focused on the phytochemical screening, anti-microbial, anti-oxidant and cytotoxic activity
of Calotropis gigantea plant extracts (stem, leaf & flower) on HCT-116 Human Colorectal adenocarcinoma cell
lines. The crude extract of C. gigantea stems, leaves & flowers were prepared using distilled water as solvent. The
plant extract was subjected to the phytochemical test; anti-microbial studies, anti-oxidant studies and the cytotoxic
activity was tested using MTT assay. The phytochemical screening of C. gigantea plant extracts showed the
presence of alkaloids, glycosides, tannins, steroids and tri terpenoids, flavonoids, proteins and phenols etc. Antimicrobial
studies showed results for Pseudonomos aeruginosa, Klebsiella pneumonia and Aspergillus niger. The
anti-oxidant study was performed by SOD assay. The IC 50 value with effective anticancer activity for stem
extract was found to be 37.30%. The results suggest that the chemical compounds present in the extracts of C.
gigantea could further be exploited as effective anticancer agents.

Keywords: Calotropis gigantea, Cancer, Phytochemicals, MTT assay, SOD assay.


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