Bikram Sarkar and Ankush Biswas*


Prostate cancer remains a significant global health concern, necessitating continuous exploration of novel
therapeutic strategies to enhance treatment efficacy and mitigate side effects. This review examines the emerging
role of dendrimers in revolutionizing prostate cancer therapy. Dendrimers, precisely engineered nanostructures
with well-defined branching, offer unique advantages, including customizable surface functionalities, controlled
drug release, and the ability to encapsulate various therapeutic agents. Recent studies highlight dendrimers as
promising carriers for chemotherapeutic drugs, gene therapy vectors, and imaging agents in the context of prostate
cancer. Their ability to penetrate biological barriers, such as the blood-brain barrier, and selectively accumulate in
tumor tissues holds great potential for improving drug delivery precision. Additionally, dendrimers exhibit
reduced systemic toxicity, enhancing the overall safety profile of therapeutic interventions. This review provides
an overview of recent preclinical and clinical studies evaluating dendrimer-based therapies for prostate cancer.
From enhanced drug delivery to targeted gene silencing and imaging modalities, dendrimers present a versatile
platform for multifaceted treatment approaches. Furthermore, we discuss the challenges and future directions in
the development and translation of dendrimer-based therapies, emphasizing the need for rigorous clinical
investigations to validate their efficacy and safety in diverse patient populations. In conclusion, dendrimers
represent a cutting-edge frontier in prostate cancer therapy, offering a plethora of opportunities to improve
treatment outcomes while minimizing adverse effects. As research in this field progresses, dendrimer-based
therapies may soon play a pivotal role in reshaping the landscape of prostate cancer treatment.

Keywords: Prostate cancer, Therapeutic strategies, Dendrimers, Nanostructures, Drug delivery, Chemotherapeutic drugs, Gene therapy vectors, Imaging agents, Biological barriers, Blood-brain barrier.

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