UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF FEXOFENADINE IN BULK AND TABLET DOSAGE FORM
Varre Maneesha, Madipelly Asmitha, Godishala Prashanth, Velpula Sunil, Buma Srikant and Srinivas Chinta*
ABSTRACT
A simple and economical Spectrophotometric method has been developed for the estimation of Fexofinadine in bulk form as well as marketed formulations. The present UV method is based on the measurement of absorption at a maximum of 259 nm using 2-propanol as a solvent. The stock solution of Fexofinadine was prepared and subsequent suitable dilution was prepared in 2-propanol to obtain a standard curve. The standard solution of Fexofinadine shows absorption maxima at 259 nm. The estimation of Fexofinadine was done at 259 nm in 2-propanol using a UV-visible double-beam spectrophotometer. In the developed method, linearity over the concentration range of 0.1-1.5 µg/ml of Fexofinadine was observed and was found in agreement with Beer’s law. The linear regression was found to be 0.998 and the percentage purity was also determined at 101%, which was within the limit as per the IP. It could be concluded from the results obtained in the present investigation that the method for estimation of Fexofenadine in pure form and in pharmaceutical dosage form is simple, rapid, and economical and can be used, successfully, in the quality control of pharmaceutical formulations and other routine laboratory analysis.
Keywords: UV spectrophotometric, Linear regression, Pharmaceutical dosage, Fexofenadine and Quality control.
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