ANTIHYPERURICEMIA ACTIVITIES OF SEVERAL ACTIVE COMPOUNDS FROM MEDICINAL PLANTS: A REVIEW
Anisha Amalia, Dzakiah Salsabillah Romdon, Nida Kusumawati, Malika Amalia Salsabila, Neshya Dhiya Afifah, Regita Shaomitha, Elsa Loviana Putri, Choerul Fazri Muhammad, Abdillah, Nabilah Putri Mulyana, Fanisa Utari, Annisa Indah Rahmawati, Enjelina, Angelika Gabe Malau, Giffari Izzi Humaidi and Maulana Yusuf Alkandahri*
ABSTRACT
Due to increased uric acid production or renal uric acid excretion, hyperuricemia has been identified as a significant risk factor for gouty arthritis. This condition is characterized by an accumulation of uric acid in the bloodstream. As of now, scientists are commencing their search for novel candidate compounds for hyperuricemia drugs derived from natural substances with antihyperuricemia effects supported by empirical evidence. This is implemented in lieu of the antihyperuricemia medications that presently exhibit numerous adverse effects. Some of the active compounds that have been taken from different plants are curcumin, kaempferol, catechin, piperine, α-mangostin, luteolin, quercetin, andrographolide, apigenin, and betulinic acid. The hyperuricemic activity of numerous active compounds through distinct mechanisms has been scientifically established.
Keywords: Antihyperuricemia, Curcumin, Kaempferol, Catechins, Piperine, ??Mangostin, Luteolin, Quercetin, Andrographolide, Apigenin, Betulinic acid.
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