A COMPARATIVE EVALUATION OF INTRAVENOUS ESMOLOL, LIGNOCAINE AND LIGNOCAINE 10% SPRAY IN ATTENUATING CARDIOVASCULAR RESPONSE TO LARYNGOSCOPY AND INTUBATION.
Dr. Sheetal Songir*, Dr. Abhilekh Jain, Dr. Krishna Kumar, Shankar Agarwal and Dr. Vaishali Waindeskar
ABSTRACT
Objectives: To observe the cardiovascular changes, to study the magnitude of changes in normotensive patients and to observe the effects in attenuating the cardiovascular responses to laryngoscopy and intubation comparing three drugs. Methods: The study was carried out on 120 adult patients of either sex, in the age group 20-60 years Patients were divided into 4 groups of 30 patients each. Depending upon the drugs employed to attenuate the cardiovascular responses during laryngoscopy and intubation, Patients were randomly allocated to either group. Group I - The patients of this group received only normal saline and served as control group. Group II – The patients of this group received i/v injection 2% lignocaine hydrochloride 1.5 mg/kg body weight 2 minute before intubation. Group III – The patients of this group received 10% lignocaine spray 1.5mg/kg body weight laryngeotracheal just before intubation. Group IV –The patients of this group received i/v Esmolol 1.5mg/kg body weight 2 minute before intubation. The observations were made at 1min., 3 min., 5 min., and at 10 minutes interval. Results: The result obtained from our study with this drug found that both i/v esmolol and i/v lignocaine an effective in controlling both SBP and DBP but not by the lignocaine 10% spray. Conclusions: Esmolol were more effective than i/v lignocaine in attenuating the both SBP and DBP. While in PR only esmolol was found effectively significant and rest other not significant. Esmolol, at an intravenous bolus dose of 1.5mg/kg, "provided consistent and reliable protection against increases in both HR and BP accompanying laryngoscopy and intubation."
Keywords: Esmolol, lignocaine, laryngoscopy.
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