THE ETHANOL EXTRACT OF CLITORIA TERNATEA EXHIBITS IN VITRO ANTI-PCOS ACTIVITY BY ANTAGONIZING ESTROGEN RECEPTORS
Sowmya B. A.* and Ramesh C.
ABSTRACT
The present investigation was designed to evaluate in vitro anti-estrogen potentials of extract of Clitoria ternatea which is one of the mechanism to treat polycystic ovarian syndrome (PCOS) against breast cancer cells and also estimate its antioxidant activity. The ethanol extract of Clitoria ternatea was prepared by successive solvent extraction process using sox-let apparatus. The ethanol extract was evaluated for its in-vitro anticancer potentials against MCF-7 human breast cancer cell lines by MTT assay and concentration of the ethanol extract required to inhibit 50% of cell growth (IC50) was recorded. To determine antioxidant properties of the extract, superoxide scavenging, lipid peroxidation and DPPH methods were used and IC50 values of extracts were noted. In current study, ethanol extract of Clitoria ternatea has shown anticancer property by exhibiting significant IC50 values against growth of breast cancer cell growth. The extract has also shown significant IC50 values in superoxide scavenging, lipid peroxidation and DPPH methods and antioxidant activity was comparable to standard drug ascorbic acid. The results obtained from the present research work suggested that the ethanol extract of Clitoria ternatea possess significant in vitro cytotoxic potentials against breast cancer cells. The results also suggested that the ethanol extract have in vitro antioxidant properties.
Keywords: Anticancer activity, Clitoria ternatea, IC50 value, MTT assay and antioxidant activity.
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