FORMULATION, DEVELOPMENT AND EVALUATION OF DICTYOTA DICHOTOMA EXTRACT MEDICINAL SEAWEED CAPSULES DELIVERY SYSTEM AS AN ADVANCED PHYTOTHERAPY APPROACH FOR CANCER
Prof. Dr. Mahmoud Mahyoob Alburyhi* and Prof. Dr. Amina El-Shaibany
ABSTRACT
The Algae Dictyota Dichotoma is seaweed widely distributed in marine environment, other parts of the world, such as in Yemen, the algae are a commercially important and renewable marine resource that are being studied on the use of many industrial applications such as in food, cosmetics, dye, and medicine. Brown algae are a premising object in the food industry and prophylactic and clinical medicine. Complementary and alternative medicine has been used widely in various populations for various purposes, including emotional support and improvement of quality of life. Nowadays biologically active compounds of algae (phlorotannins, carotenoids, alginic acid, fucoidan, peptides) are being demonstrated to play a significant role in prevention of certain degenerative diseases, such as cancer, inflammation, arthritis, diabetes and hypertension. Therefore, immense biochemical diversity of algae derived from active components become a rich source of novel chemical entities for the use as functional ingredients in many industrial applications such as functional foods, pharmaceuticals and cosmeceuticals. In the present study the algae Dictyota Dichotoma were collected from Red Sea coast, Hodeida. It was prepared six formulation of Dictyota Dichotoma extract capsules. It was concluded that the best formulation F4 of Dictyota Dichotoma medicinal seaweed capsules delivery system as an advanced phytotherapy approach for cancer according to in-vitro dissolution was found to be 96.1% within 10 minutes in acid medium.
Keywords: Dictyota Dichotoma, Anticancer, Formulation, Capsule, Algae, Phytotherapy.
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