COLON TARGETED DRUG DELIVERY SYSTEM OF CELECOXIB- FORMULATION AND IN VITRO, IN VIVO EVALUATION
Subimol S. and Amjadkhan A. Pathan*
ABSTRACT
Colon-targeted drug delivery systems can provide therapeutic benefits including better patient compliance and lower costs. The present investigation is aimed to design a colon specific microbially triggered system using biodegradable co-polymer mixtures. The calibration curves of Celecoxib were measured in distilled water, 0.1N HCl and phosphate buffer of pH 6.8 and 7.4 which showed good linearity. Compatibility study of pure drugs, excipients and their physical mixtures were evaluated and passed as per standards. Solubility determination was carried out in different solvents. Satisfactory results were found from evaluation of micromeritic parameters such as flow property, in-vitro dissolution study and kinetic study. Differential scanning calorimetry studies showed no incompatibility of drug with other excipients. Drug release was accelerated in the presence of rat cecal contents and indicated the degradation of polysaccharide by colonic microflora. A short-term stability study of the optimized formulation showed no significant changes in physical appearance, drug content, and in-vitro dissolution profile when stored at 40 ± 2°C/75 ± 5% RH for 3 months. The designed system can be potentially used as a carrier for colon delivery of celecoxib by regulating drug release in stomach and small intestine.
Keywords: Celecoxib, Colon, Targeted drug delivery system, RP-HPLC.
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