European Journal of Biomedical and Pharmaceutical Sciences

ANTIHYPERGLYCAEMIC ACTIVITIES OF PLANT-EXTRACTED SUCCINIC ACID AND HEXAMETHYLCYCLOTRISILOXANE IN DIABETIC ALBINO RATS

Chidimma E. Opara, Samuel C. Iwuji*, Peter C. Onyebuagu, Ikechukwu V. Akalonu, Rowland I. Oplekwu and Churchill C. Ogbonna

ABSTRACT

This study investigated the in vivo activities of these plant-extracted Succinic acid and hexamethylcyclotrisiloxane as antihyperglycaemics in alloxan-induced diabetic Wistar rats. The experiment was conducted in a standard animal house in Enugu State University of Science and Technology (ESUTH), Faculty of Pharmaceutical Sciences, Department of Pharmacology, Agbani, Enugu State. The animal models were randomly divided into seven groups, and Fasting blood glucose level test was conducted to determine the antihyperglycaemic effects of these phytochemicals on alloxan-induced diabetic rats. After four weeks of treatment, the results showed that the diabetic group treated with 100mg/kg b.w of Succinic acid only and 200mg/kg b.w. of combined Succinic acid and Hexamethylcyclotrisiloxane (1:1) for the single effect and combined effect groups, respectively, showed more significant recovery effects on the alloxan-induced diabetic rats than the 100mg/kg b.w. hexamethylcyclotrisiloxane only and 100 mg/kg b.w. of combined Succinic acid and hexamethylcyclotrisiloxane (1:1). Data from this experimental research showed a significant recovery at P< 0.05 from hyperglycemia. These findings suggest that Succinic acid and Hexamethylcyclotrisiloxane when administered either as single or combined therapy for four weeks could elicit a dose-dependent effect on blood glucose level normalization and body weight maintenance.

Keywords: Antihyperglycaemics, Succinic acid, Hexamethylcyclotrisiloxane, Diabetes.