FORMULATION AND EVALUATION OF DAPSONE-LOADED MICROSPHERE GEL FOR THE TREATMENT OF ACNE VULGARIS
Athira K.*, K. Vineetha, Krishnananda Kamath K. and A. R. Shabaraya
ABSTRACT
Microspheres are solid spherical particles ranging in size from 1-1000μm consisting of proteins or synthetic polymers which are biodegradable in nature. The present study is to investigate the effectiveness of Dapsone microsphere gel for the treatment of acne vulgaris. Dapsone is a sulfone antibiotic with an anti-inflammatory effect, which is considered to be accountable for its effectiveness in the treatment of acne vulgaris. Six different(F1-F6) formulations of dapsone microspheres are prepared, F1-F3 with ethyl cellulose in different concentration and F4-F6 with Eudragit L 100 in different concentrations. The best formulation was chosen on the basis of their entrapment efficiency, which is then incorporated into the carbopol 934 gel. The prepared gel was then evaluated for its parameters like physical appearance, pH, drug content, spreadability, viscosity, In vitro diffusion studies and Kinetic studies. Results revealed that the entrapment efficiency of the F6 was found to be 80.14±0.36% which is higher than the other formulations which is in micro-size range (85.65 ± 6.57 μm) and showed cumulative drug release of 61.477%. SEM analysis illustrated spherical and uniform microparticles. The developed micro formulation showed improved stability and the obtained results corroborate the premise that dapsone loaded microsphere gel can be an effective strategy for acne management.
Keywords: Dapsone, Microspheres, Solvent evaporation method, Carbopol gel.
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