Abstract
STUDY OF ANTI-PROLIFERATIVE ACTIVITY OF TRI-ACETOXY CUCURBITACIN ISOLATED FROM DRY SEED OF WILD CUCUMBER (JANGLI KHIRA)

Ajoy K. Bauri*, Gerardo Anaya Eugenio and Esperanza J. Carcache De Blanco*

ABSTRACT

Chemical profiling of methanol extract of seed of wild cucumber revealed the presence of a triterpenoid as major constituent. Structural determination of this triterpenoid has been carried out by chemical, spectral, and spectrometric methods and was identified as tri-acetoxy cucurbitacin. The anti-proliferative activity of this compound has been carried out on four different human cancer cell lines. It exhibited potent inhibitory activity against different human cancer cell lines named as prostate (DU-145), breast (MCF-7), cervical (HeLa) and colon (HT-29) cancer cell lines using SRB assay in comparison with therapeutically used standard drug, paclitaxel as control. Bioassay result exhibited the most significant activity against aforesaid cell lines with inhibitory concentration, IC50 values 27.1±1.5, 24.9 ±0.8, 34.8 ±3.4, 26.3 ± 2.4 μM level respectively.

Keywords: Wild Cucurbita seed; isolation; structural characterization; triterpenoid; tri-acetoxy cucurbitacin; cell cytotoxicity; SRB assay.


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