A STUDY ON THE EFFECT OF VISFATIN ON GASTRIC EMPTYING AND INTESTINAL MOTILITY
Dr. Mohamad Yosof Rezk*
ABSTRACT
Background: Visfatin is a novel adipokine (originally known as pre-B cell colony-enhancing factor) shows altered plasma levels in different disorders, e.g. type-2 diabetes mellitus, obesity, fetal growth retardation and gestational diabetes mellitus. Aim: We found that no study demonstrated the effect of visfatin on gastrointestinal motility in experimental animals. We investigated the effect of visfatin on gastric emptying and intestinal motility. Methods: This work was carried out in 2 different parts: 1st part measurement of gastric emptying: 42 adult male albino rats were subdivided into 7 equal groups: Control (N) group, Visfatin (V1)1nM, (V2)10 nM, (V3)100 nM, V2+ FK866(1nM), V2+ FK866(10nM) and V3+ FK866(100nM). 2nd part measurement of intestinal motility: 12 adult male guinea pigs were subdivided into 2 groups: Visfatin (V1) small dose group: intestinal rhythmic contractions were measured and considered to be the control group then visfatin was added in different doses (1nM, 10 nM and 100 nM). Visfatin with FK866: intestinal rhythmic contractions were measured then visfatin was added in maximal dose 100nM, then FK866 was added 8 minutes before visfatin. Results and conclusion: visfatin was found to have a significant inhibitory effect on gastric emptying and intestinal motility. This effect of visfatin was completely blocked by FK866 (a competitive visfatin inhibitor).
Keywords: visfatin- intestinal - motility- gastric - emptying- adipokine.
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