FORMULATION AND EVALUATION OF SELF-MICRO EMULSIFYING DRUG DELIVERY SYSTEM OF PITAVASTATIN CALCIUM
*Babulal, Dr. Brajesh Kumar Arjariya, Praveen Bhavsar and Sheenam Mansuri
ABSTRACT
The formulation and evaluation of self-micro emulsifying drug delivery systems (SMEDDS) present a promising strategy to address the challenges associated with the poor solubility and bioavailability of Pitavastatin calcium, a potent statin utilized for managing dyslipidemia and preventing cardiovascular events. SMEDDS formulations consist of oil, surfactant, and co-surfactant components, designed to spontaneously form fine oil-in-water emulsions upon dilution with gastrointestinal fluids, thereby facilitating drug solubilization and absorption. By leveraging the principles of SMEDDS technology, the aim of this study is to enhance the solubility, dissolution, and ultimately, the bioavailability of Pitavastatin calcium. Key parameters such as droplet size, zeta potential, and in vitro dissolution profile are systematically evaluated to optimize the SMEDDS formulation. Through comprehensive characterization and evaluation, the study seeks to elucidate the potential of SMEDDS as an effective drug delivery system for Pitavastatin calcium. In conclusion, the formulation and evaluation of SMEDDS for Pitavastatin calcium represent a promising avenue to improve the therapeutic efficacy and patient compliance of this important cardiovascular medication. This research contributes to the development of innovative drug delivery systems with the potential to enhance treatment outcomes and patient well-being.
Keywords: Pitavastatin calcium, Self-micro emulsifying drug delivery system (SMEDDS), Formulation, Evaluation.
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