European Journal of Biomedical and Pharmaceutical Sciences

APPLICATION OF FLOW CYTOMETRY IN THE DIAGNOSIS OF ACUTE LEUKEMIA IN CHILDREN: KING HUSSIEN MEDICAL CENTER EXPERIENCE

*Bayan Al-Zghoul MD, Mohammad J. Maaita MD, Tania Ogeilat MD, Malak Al-Awamleh MT, Areen Al-Zgoul MD, Alaa Abu-Alkeshek MD, Mashael Khalayleh MD, Falah Faragat MD, Mothana Al-Nawaflh MD, Mohammad Masallha MD, Dima Al-Dabbas MD, Abdallah Shawabkeh MD and Hashim Shawabkeh MD

ABSTRACT

Background: Acute leukemia is a group of clonal hematopoietic stem cell neoplasms. Flow cytometry plays a significant role in diagnosis of acute leukemia. Aim: To spot on the central role of flow cytometry in the diagnosis of acute leukemia. Patients and Method: We reviewed flow cytometry results of 130 patients during the period from January 2019 to December 2023. Results: 130 patients aged between 3 months to 14 years with a mean age of 7 years. Male to female ratio 1.4:1. Acute lymphoblastic leukemia of B-cell lineage (B-ALL) 87 patients (67%). Acute lymphoblastic leukemia of T-cell lineage (T-ALL) 18 patients (13.8%). Acute myeloid leukemia (AML) 25 patients (19.2%). Conclusion: Flow cytometry is a golden tool for the diagnosis of acute leukemia.

Keywords: Flow cytometry, acute leukemia, diagnosis.