European Journal of Biomedical and Pharmaceutical Sciences

EFFECT OF CRUDE EXTRACT OF SECURIDACA LONGIPEDUNCULATA ON ISOLATED RABBIT HEART

*Salami H. A., Ayo J. O., Adelaiye A. B. and Olorunshola K.V.

ABSTRACT

The plant securidaca longipedunculata is used in folklore medicine to treat cardiovadcular disorder evaluated. The effect of ethanollic extract of the root bark of securidaca longipedunculata (EESL) on isolated rabbit heart (New Zealand weighing between 2-3kg) were assessed in Langedorff – isolated rabbit heart. EESL showed a dual effect on heart rates and coronary flow, low dose caused significant (P<0.001) increase in coronary flow rate and heart rate while the opposite effect was observed at high dose. A gradual increase (P<0.001) in coronary perfusion pressure was observed with increasing concentration of EESL. With interventricular root infusion the extract evolved a depressant effect on heart rate and cardiac output, while ventricular pressure was significantly (P<0.001) high at high dose, than at the base line level. Co-administration of nifedipine with the extract antagonized the effect of extract on coronary circulation.

Keywords: Isolated Rabbit heart, securidaca longipedunculata, coronary artery and nifedipin.