THE INFLUENCE OF OMEPRAZOLE ON LIPID PROFILE OF PATIENTS WITH ACID PEPTIC DISEASE
Neveen Ahmad Al-Alian Ph*, Nadia Ahmad Al Omari Ph*, Mohammad Bassam Jalayleh Ph*, Lujain Emad Nsour Ph*, Ghofran Nedal Al Alaween Ph*, Dr. Bilal Smadi** and Laith Safadi***
ABSTRACT
Objective: To evaluate the effect of omeprazole on the lipoprotein fractions of patients with acid peptic disease.
Patients and Methods: Eighty five patients suffering from acid peptic disease who treated with omeprazole were enrolled in this prospective study. Prior to enrollment, all patients had an investigation of lipoprotein fractions (serum cholesterol, triglycerides, HDL and LDL), and only those with normal results were included in the research. A fasting blood test was obtained from all patients to evaluate lipid profile at zero, four, eight, twelve and sixteen weeks following therapy. Results: The total number of patients included in this study was eighty five; only sixty patients came for regular follow and were tested for lipid profile. There were forty three males and seventeen females. Age of patients ranged between 19-46 years (mean 32.1 years). Regarding the body weight of patients, it was ranging between 50-93 kg (mean 57.2 kg). None of the included patients had history of alcohol consumption. There was no objective or subjective side effects among the patients. Serum cholesterol, Triglycerides, LDL and HDL were within normal range after four, eight, twelve and sixteen weeks after treatment. Conclusion: Omeprazole had no significant impact on lipid profile of individuals with acid peptic illness when administered for a duration of twelve weeks. However additional trials with big number of patients are required.
Keywords: Omeprazole, lipid profile, acid peptic disease.
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