European Journal of Biomedical and Pharmaceutical Sciences

EVALUATION OF THE DISCRIMINATORY POWER OF RECEIVER OPERATING CHARACTERISTIC (ROC) CURVE ANALYSIS IN IDENTIFYING CARDIO METABOLIC RISK IN TYPE II MALE DIABETICS

*Dr. Sakina Raghib and Dr. Sabiha Vali

ABSTRACT

The study explores the rational of ROC analysis for cardio metabolic risk (CMR) in type 2 male diabetics with a mean age of 49.98±10.74. Obesity indices were assessed and Receiver Operating Characteristic (ROC) Analysis was performed independently on 200 male diabetic subjects. Statistical significance was obtained corresponding to AUC of each parameter. Cut off values as determined by Youden’s index were 23.30 kg/m2(BMI), 90.50 cm (WC), 1.01(WHR) and 0.54 (WHtR). The optimum cut off for WHtR remained close to the standard cut off value of 0.5 indicating WHtR as the best predictive value for evaluating metabolic risk. The AUC for WHR is observed to be the lowest and insignificant (AUC 0.590, p=0.067) amongst all the four indices. AUC for WC is significantly high (AUC 0.753, p <0.0001) while WHtR showed AUC of 0.737(p<0.001) thereby confirming its ability to be a better predictor of cardio metabolic risk factors followed by BMI (AUC 0.687, p<0.0001). The study validates the usefulness of ROC as an evaluation tool for identifying diabetics at cardio metabolic risk.

Keywords: Cardio Metabolic Risk, Youden’s Index, Area Under Curve (AUC).