European Journal of Biomedical and Pharmaceutical Sciences

A REVIEW: HERBAL FORMULATION FOR ITS ANTIULCER ACTIVITY

Nandlal, Umesh Chandra and Sanjay Kushwaha*

ABSTRACT

This study examines the potential of herbal formulations in the management of peptic ulcers, focusing on their mechanisms of action, efficacy, safety, and implications for clinical practice. Peptic ulcers are a common gastrointestinal disorder characterized by mucosal erosion in the stomach or duodenum, often associated with factors such as Helicobacter pylori infection, nonsteroidal anti-inflammatory drug (NSAID) use, and stress. Conventional treatments for peptic ulcers include proton pump inhibitors (PPIs), H2-receptor antagonists, and mucosal protective agents, which effectively reduce gastric acidity and promote ulcer healing. Herbal formulations have gained attention for their potential as complementary or alternative treatments for peptic ulcers. These formulations contain bioactive compounds derived from plants, which exert various pharmacological effects such as anti-inflammatory, antioxidant, cytoprotective, and antimicrobial properties. Mechanisms of action include modulation of gastric acidity, enhancement of mucosal protection, inhibition of inflammation, and promotion of tissue repair. Herbal formulations offer several advantages, including favorable safety profiles, affordability, and accessibility. Overall, herbal formulations represent promising therapeutic options for peptic ulcer management, offering holistic approaches to gastrointestinal health and potential benefits for patient-centered care. Further research is needed to elucidate optimal dosing regimens, long-term safety, and potential drug interactions associated with herbal treatments for peptic ulcers.

Keywords: Peptic ulcers, Herbal formulations, Alternative medicine, Mechanisms of action.