Abstract
EFFECT OF AQUEOUS MIMOSA PUDICA EXTRACT IN SULPHONAMIDE-INDUCED LIVER DISEASE IN ALBINO WISTAR RATS

Usiobeigbe O. S., Omolumen L.E., Airhomwanbor K.O., Ugege C., Asibor E., Ikede R.E., Ayeni O.M.

ABSTRACT

Mimosa pudica comes from the word "mimic", which hints at leaf sensitivity, and "pudika", which means shy, modest, or shy. Mimosa mimics the susceptibility of animals to sundew, which responds to contact with insects, such as light, time, and gravity. Plants have played a significant role in maintaining human health and improving the quality of human life for thousands of years and have served humans well as valuable components of medicines, seasonings, beverages, cosmetics and dye. This topic is aimed to study the effect of Mimosa pudica in sulphonamide-induced liver disease in albino wistar rat. Liver damage in rats caused using sulphonamide (1ml/kg /bw), administered orally. Parameters such as serum alkaline phosphatase (ALP) and bilirubin (total and direct). Silymarin (100mg/kg) was used as the standard drug. The effects of ethanolic extract of Mimosa pudica (400mg/kg) was observed on the following parameters. One group was given both ethanolic extract of Mimosa pudica and Silymarin to observe if there was any additive effect. The statistical analysis of data was done by using Chi-Square. There was comparison of the mean values of the liver function parameters in Group 1 where there was no administration of liver inducing agent like Sulphonamide or the liver damage reversers like the plant extract Mimosa pudica or the Standard drug (silymarin), with the same parameters in other groups of different patterns of treatment. There was statistically significant increase in the mean values of serum alanine transaminase, aspartate transaminase, total protein, albumin, globulin, alkaline phosphatase, gamma-glutamyl transferase and AST/ALT ratio in Group 2, Group 4 and Group 5 with p-values (p<0.01), (p<0.01), (p<0.01), (p<0.05), (p<0.01), (p<0.01), and (p<0.01) respectively. This shows that the liver damage was not reversed where there was no administration of liver damage reversing agent, also, the administration of 100mg and 200mg of plant extract Mimosa pudica were not sufficient to reverse the damage caused to the liver and administration of 300mg of Mimosa pudica was enough to reverse the liver disease. This study shows that Mimosa pudica extract was potent enough to reverse liver- induced disease. It also shows that certain concentration (300mg) of Mimosa pudica extract was used to reverse the liver-induced disease. Finally, the study shows that there is a significant relationship between liver enzymes and liver disease.

Keywords: Mimosa pudica, Liver disease, Sulphonamide, Wistar rat, Livere parameters.


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