DESIGN AND EVALUATION OF ORAL MEDICATED JELLY OF BARICITINIB
Pallavi Vadlamudi*, K. Saihema, Gvramireddy and Ramarao Nadendla
ABSTRACT
Baricitinib is a novel drug used to treat rheumatoid arthritis. The present study is aimed to design and evaluate oral medicated jellies of baricitinib using gelatin, citric acid, and sugar, sodium benzoate, sodium citrate, xanthan gum. The prepared jelly was analyzed for weight variation, surface pH, content uniformity, syneresis, viscosity, in-vitro dissolution studies, stability studies, and in-vivo pharmacokinetic parameters. The in-vitro dissolution test of the jellies was performed in pH 7.4 buffer using USP type- II (paddle) at 50rpm. All the formulations showed more than 70% of drug release within 20mins. Except for xanthan gum and gelatin, all other variables in this study are constants. 32 factorial designs were employed, a total of 9 formulations were generated as a consequence. F8 is the optimal formulation with the use of contour and 3D plots. Stability studies of the formulated jellies were carried out as per ICH guidelines for 3 months of different humidity and temperature conditions. The optimized F8 formulation has given highest drug release. These oral medicated jellies avoids first-pass metabolism, rapid onset of action, and high bioavailability.
Keywords: Baricitinib, Arthritis, medicated jelly, contour plots, factorial design.
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