European Journal of Biomedical and Pharmaceutical Sciences

THE INFLUENCE OF GENDER AND HLA-B51 ON THE CLINICAL MANIFESTATIONS OF BEHCET DISEASE AMONG JORDANIAN PATIENTS

Dr. Mazin Al Zo’ubi*

ABSTRACT

Introduction: Bechet’s disease (BD) is a multi-system inflammatory disorder with diverse clinical features influenced by region, ethnicity, gender, and HLA-B51. Aim: we aimed to investigate the influence of gender and HLA-B51 on the clinical manifestations of BD among Jordanian patients. Methods: We reviewed 108 BD patients' records from our rheumatology clinic who met the ICBD criteria. Age and gender were noticed for each patient. We collected clinical and laboratory data, and confirmed oral ulcer, genital ulcer, ocular, joint, vascular, and neurological involvement, and HLA-B51 status. We compared clinical features by gender and HLA-B51 using chi-square test and SPSS 24.0. We set p-value at < 0.05. Results: We examined 108 BD patients (mean age 32.6+10.1, 80% male, 4:1 M:F ratio). All had oral ulcers, 73% genital ulcers, 45% skin lesions, 28% vascular complications, and 50% HLA-B51 positive. No significant differences in major organ involvement by gender or HLA-B51 were found. Conclusion: We found different BD phenotypes in Jordanians, unaffected by gender or HLA-B51. More studies with different criteria are needed to examine these factors on BD symptoms.

Keywords: Bechet’s disease, HLA-B51, Gender, Clinical manifestations.