EVALUATION OF ANTI-HELMINTIC ACTIVITY OF ETHANOLIC EXTRACT OF WHOLE PLANT OF RUTA GRAVEOLENS [EERG]
Dr. G. N. Pramodini*, Dr. Shaik Mohammed Khasim, Sumaiya Khatoon, Shaik Imtiyaz, Syed Anas, Md. Arif Baig and Mohammed Abdul Malik
ABSTRACT
In Recent years there has been rapid increase in the infections caused by the helminthes and their development of resistance to most of the commercially available anthelimentics drugs. so, Plants clamied for possessing the anthelmintic property is getting attention these days. The traditionally clamied anthelimintics are sustainable and environmentally acceptable crude drugs. so, The present study is based on to evaluate the anthelimintic potential of ethanolic extract of Ruta graveolens.L whole plant by using Pheretima Posthuma as test worms (100mg/ml, 50mg/ml, 25mg/ml) of Ruta graveolens.L whole plant ethanolic extract were tested in the assay, which involved determination of time of paralysis (P) and time of death (D) of the worms it showed shortest time of paralysis (P=22 min) and death (D=41min) in 100mg/ml, while the time of paralysis and death will increase in 50mg/ml (P=25min) and D=47min) and in 25mg/ml concentration (P=31min) and (D=60min) respectively as compared to albendazole 10mg/ml used as standard reference (P=20min) and (D=43min) and normal saline as control. The results of present study indicated that the ethanolic extract Ruta graveolens.L (EERG) whole plant showed potential therapeutic significant paralysis and also caused death of worms. so it is concluded that the plant Ruta graveolens.L proved for its traditional claim as an effective anhelimintic herbal drug.
Keywords: Ruta graveolens, anthelimentics, albendazole, Time of paralysis, time of death.
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