TRANSFEROSOMES: INNOVATIVE VESICLES FOR EFFICIENT TRANSDERMAL TRANSPORTATION
Umamaheswari D.*, Abdul Hasan Shathali A., Balaji R., Sheik Abdulla Kapoor M., Ponraj S., Vinodha G.
ABSTRACT
Transferosomes are novel vesicular drug delivery systems characterized by ultra-flexible lipid bilayers, enabling efficient penetration through biological barriers. Transferosomes are composed of phospholipid bilayers with added edge activators, such as surfactants or bile salts, which impart high deformability to the vesicles. This deformability allows transferosomes to squeeze through narrow pores and permeate deep into the skin, mucous membranes, and other tissues, overcoming the limitations of traditional liposomes. These vesicles can encapsulate a wide range of drugs, including hydrophilic and hydrophobic compounds, peptides, and nucleic acids, offering versatility in drug delivery. Transferosomes have shown promising potential in various therapeutic applications, including transdermal drug delivery, ocular drug delivery, and targeted drug delivery to tumors and inflammatory sites. Their ability to enhance drug absorption, improve bioavailability, and minimize systemic side effects makes them an attractive option for pharmaceutical formulations. This review provides an overview of transferosomes, focusing on their structure, advantages, disadvantages, and materials used for formulation, and evaluation techniques of transferosomes, as well as their potential applications in drug delivery.
Keywords: Edge activators, Liposomes, Transferosomes, Vesicular drug delivery.
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