Abstract
EXPLORING SPANLASTIC: AN ADVANCED VESICULAR DRUG DELIVERY SYSTEM

Navami R. Alva*, Vineetha K. and Krishnanandha Kamath K.

ABSTRACT

In recent years, Vesicles have become the choice of drug delivery. Vesicular drug delivery systems are valuable in evading drawbacks that are associated with conventional dosage forms. Hence Novel drug delivery system such as liposomes, nanoparticles, nanoemulsion, nanosuspension, are been designed to achieve better delivery of drug. In 2011, Spanlastic is evolved as one of the better vesicular drug delivery system. These are the elastic vesicular nanocarrier that entraps the drug in the core cavity in the form of bilayer. They are made up of surfactants that are surrounded by aqueous solution. Spanlastics are chemically stable when compared with other vesicular nanocarriers. These offers targeted delivery and regulated release of medicinal substance and improves drug availability at the site of action. The current review summarizes the structure, advantages, composition, mechanism of drug penetration, method of preparation, evaluation and applications of Spanlastics in drug delivery and targeting.

Keywords: Spanlastics, Vesicular drug delivery, Nanocarrier, Thin film Hydration, Modified Spray technique.


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