COMPARATIVE STUDY OF ONE POT SYNTHETIC METHODS OF 2-AMINO-1,3,4-THIADIAZOLE
Ankita Jamale*, Ahilya Mudhe, Ajinkya Patil, Akshay Khadake, Akash Bageli, Baliram Sarvade, Amit Panaskar, Bhagyashri Panaskar and Vishal Ghadage
ABSTRACT
Thiadiazole derivatives have garnered significant attention in the field of medicinal chemistry due to their diverse pharmacological activities, including anticancer, antimicrobial, antibacterial, antifungal, insecticidal and pesticidal properties. This article presents the synthesis of a series of thiadiazole derivatives and investigates their chemical characterization and potential pharmacological effects on various cell lines. Thiadiazoles belong to the classes of nitrogen–sulfur heterocycles with extensive application as structural units of biologically active molecules and as useful intermediates in medicinal chemistry. The potency of the thiadiazole nucleus is demonstrated by the drugs currently used. 1,3,4-Thiadiazoles and some of their derivatives are extensively studied because of their broad spectrum of pharmacological activities. In this article Substituted Carboxylic acid condensed with Thiosemicarbazide to form 2-amino-5- substituted 1,3,4-Thiodiazole in various reaction conditions. All products are characterized by elemental analysis.
Keywords: 2-Amino-1,3,4-Thiadiazole, Elemental Analysis, Thiosemicarbazide, One Pot Synthetic Methods, Thionyl Chloride, Ultrasonic Irradiation.
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