European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF ITRACONAZOLE MEDICATED CHEWING GUM FOR ORAL CANDIDIASIS

K. Ajith Kumar*, Dr. V. Kalvimoorthi, L. Gopi, Dr. K. Kaveri and D. Jeeva

ABSTRACT

Chewing gum is one of the most popular dosage form, used for delivering the many active components. Most of the chewing gums were used for smoking cessation (containing the nicotine) and also used for oral and dental hygiene. Itraconazole is an anti-fungal drug. It is one of the active ingredients used to treat oral candidiasis. In the present work medicated chewing gum of Itraconazole was developed to treat oral candidiasis. The study includes formulation and evaluation of medicated chewing gum of fluconazole. The chewing gum formulations were made using a gum base. The concentration of gum base was varied in the formulation to study its effect on in-vitro drug release. Formulations were developed by conventional/traditional method. The prepared formulations were evaluated for various parameters like physical appearance, weight variation, drug content in-vitro and in-vivo drug release behavior. Stability studies were conducted. From this study it could be concluded that it is possible to design medicated chewing gum containing Itraconazole, mainly for the treatment of oral candidiasis and related conditions.

Keywords: Medicated chewing gum, Itraconazole, Oral candidiasis, Conventional/traditional method.