FORMULATION AND EVALUATION OF NOVEL GUM BASED MEDICATED CHEWING GUM FOR TOOTHACHE
Dr. Ojas Patela*, Mona Patel, Vishal Pawar, Vandana Bhoya, Ashish Vahut, Riya Halpati and Drasthi Vaghela
ABSTRACT
Chewing gum is a drug delivery system which is going to advance more and more in nowadays researches and it seems to get more standardized in future industry because it can deliver either pharmaceuticals or nutrients which are known as medicated chewing gum (MCG) and non MCG. MCG is supposed to act as an extended release dosage form that provides a continuous release of medicine contained. Ability of chewing gums to release active ingredients into the oral cavity, steady and rapid action, capability of both systemic and local delivery, make it appropriate for extensive use in food and pharmaceutical industries. Oral health is become more and more concerned with appearance, notably the appearance of white teeth. Satins caused by chromogens from food, drink, or smoking can be extrinsic or intrinsic, depending on the source. Oral malodor is caused by anaerobic gram- negative bacteria adhering to the tongue or associated with periodontitis, which produces VSCs such as hydrogen sulfide 3methyl perception. Chewing gum is a mixture of ingredients either natural or synthetic that comprises water-soluble bulk portion and water soluble bulk portion and water insoluble gum bases. Chlorhexidine, Clove Oil, Poly vinyl acetate, Xanthan, Polyethylene glycol 4000 (PEG-4000), Sorbitol, Peppermint oil, Butylated hydroxytoluene (BHT), Glycerin were used for this preparation. Its prepared by two methods and evaluated by different parameters like Mass uniformity , organoleptic properties, Stickiness , Test for hardness/plasticity etc.
Keywords: Chewing gum, Chlorhexidine, Clove Oil, Mass uniformity, organoleptic properties, Stickiness, plasticity.
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