A REVIEW ON IN SITU GELS
Keerthana Y. L.*, Bhavyashree T. and Krishnanandha Kamath K.
ABSTRACT
Recently, controlled and sustained drug delivery has become the standard in modern pharmaceutical design and intensive research has been undertaken in achieving much better drug product effectiveness, reliability and safety. The in situ gel forming polymeric delivery systems have shown benefits such as ease of administration and reduced frequency of administration, improved patient compliance. Various approaches like physiological stimuli, ion-activated system etc result in the formation of in situ gels. Generally, two methods are used for the preparation of in situ gels such as cold method and hot method. Both natural and synthetic biodegradable polymers are used for the formulation of in situ gels such as pectin, alginic acid, gellan gum, xyloglucan, carbopol etc. In situ gels are evaluated for their physical strength, appearance, viscosity, spreadability and in vitro studies. Mainly in situ gels are administered by oral, ocular, rectal, vaginal, injectable and intraperitoneal routes. Overall, this review focuses on the introduction to in situ gels, various approaches utilized, various polymers used, its evaluation, and applications.
Keywords: In situ gels, Ion activated system, Cold method, hot method etc.
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