ANTIDIABETIC ACTIVITY OF ERYHTROXYLUM MONOGYNUM IN ALLOXAN INDUCED DIABETIC ALBINO RATS
R. Vijay Kumar*, G. Venkat Raji Reddy, B. Prabhakar And M. Krishna Reddy
ABSTRACT
Among metabolic disorders Diabetes is widely spread around the
world. Lack of exercise, bad food habits, stress, heredity are some of
the reasons which may cause diabetes. Medicine available to diabetes
is not completely targeting the problem. The plants are well known for
their therapeutic nature. The Indian ethics are very good source for the
remedies. The present study was carried out to evaluate the antidiabetic
activity of Erythroxylum monogynum plant extract in alloxan
(150mg/kg) induced diabetic rats. The extract was prepared with hydroalcohol solvent (70%
ethanol and 30% water) through maceration technique. Alloxan induced rats with above 150
mg/dL blood glucose levels were selected for the study. These rats were divided into 5
groups. Group- I was control, group-II was alloxan induced rats, group-III was alloxan +
Metformin 500mg/kg and group-IV was alloxan + Extract 200 mg/kg and group-V was
alloxan +Extract 300mg/kg with 8 rats in each group. The treatment was carried out by oral
for 14 days. The blood samples were collected from retro orbital plexus on 15th day and
centrifuged to separate serum. The serum samples were performed serological tests. The
serum glucose levels were decreased in the extract treated rats. The values of SGOT (Serum
Glutamate Oxaloacetate Transaminase), SGPT (Serum Glutamate Pyruvate Transaminase)
and ALP (Alkaline Phosphotase) were decreased in group-IV and V compare to the group-II.
The reduced serum cholesterol, triglycerides, LDL (Low Density Lipoproteins) and VLDL
(Very Low Density Lipoproteins) were also seen in group-IV and V rats. The HDL values
were increased in the extract treated diabetic rats. The results were significantly comparable
with group-III. The reduced glucose levels, SGOT, SGPT, ALP, cholesterol, triglycerides, VLDL and LDL and increased HDL values were explaining the antidiabetic activity of the
extract.
Keywords: Diabetes, alloxan, glucose, SGOT, SGPT.
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