European Journal of Biomedical and Pharmaceutical Sciences

STUDY OF ANTI-PROLIFERATIVE ACTIVITY OF PHENOLS FROM THE FRUIT RIND OF M. MALABARICA

Ajoy K. Bauri*, Ines Castro Diomicio, Eric Salinas Arellano, Sabine Foro and Esperanza J. Carcache de Blanco

ABSTRACT

M. malabarica (family: Myristicacae) is an Indian medicinal plant used as folklore medicine from very ancient time to cure various kind of diseases reported in Ayurved and fruit rinds are also used as an active ingredient for preparation of exotic spices known as ‘garam masale’. Chemical profiling of methanol extract of defatted rind revealed the presence of a diarylnonanoids, a class of compounds generically known as malabaricones, as major constituents. Structural determination of these compounds has been conducted by physical, chemical, spectral, and spectrometric methods in comparison with spectroscopic data available in literature. In vitro assay of these compounds on various cancer cell lines revealed that they exhibited anti-proliferative activity using SRB assay.

Keywords: M. malabarica; fruit rind; phenols; isolation andstructural characterization; anti-proliferative activity; SRB assay.