ISOLATION AND STRUCTURAL CHARACTERIZATION OF TRIDEPSIDES FROM POLAR FRACTION OF LICHEN (PERMETREMA PARLATUM)
Ajoy K. Bauri*, Ines Castro Dionicio, Eric Salinas Arellano, Jonathan G. Jeyaraj, Sabine Foro and Esperanza J. Carcache de Blanco*
ABSTRACT
Phytochemical investigation of more polar fraction of lichen (P. parlatum) led to the isolation of four known tridepsides (1-4) along with a new depside (5). They were identified as β-hydroxy methyl ester of gyrophoric acid, methyl ester of lasallic acid, methyl ester of crustinic acid, methyl ester of hiascic acid and 4-carboxy lecanoric acid. The structures of known tridepsides (1-4) were identified in comparison with their 1H NMR, 13C NMR and HRESI-MS spectral data available in literature. The structural determination of new depside (5) was carried out both 1D, 2D NMR spectroscopy and HRESI-MS spectrometry. In vitro, anti-proliferative activity assay of these compounds was conducted against various human cancer cell lines in comparison with therapeutically prescribed authentic drug paclitaxel as control using SRB assay.
Keywords: Phytochemical investigation of more polar fraction of lichen (P. parlatum) led to the isolation of four known tridepsides (1-4) along with a new depside (5). They were identified as ?-hydroxy methyl ester of gyrophoric acid, methyl ester of lasallic acid,
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