European Journal of Biomedical and Pharmaceutical Sciences

INVESTIGATING HBA1C REDUCTION AND INCIDENTS OF REPORTED HYPOGLYCAEMIA BETWEEN HUMAN INSULINS VERSUS ANALOGUE INSULINS AMONG TYPE 2 DIABETIC MELLITUS PATIENTS - A SINGLE CENTRE, RETROSPECTIVE STUDY

Yen Ping Ng*, Hui Mun Teh Jing Ng, Ying Shan Beh, Boon Seng Tan, Jin Yi Choo, Yee Mei Ng and Cheng Hoon Yap

ABSTRACT

This study aimed to determine the magnitude of difference in terms of HbA1c reduction and exploring the incidents of reported hypoglycaemia among T2DM patients receiving human insulins compared to analogue insulins. This was a retrospective study conducted in one primary public health clinic in Malaysia. All type 2 diabetes patients who fulfilled the inclusion criteria were identified and recruited for analysis. Sugar profiles and incident of reported hypoglycaemia in patients receiving human insulin versus analogue insulin were compared. No significant HbA1c reduction was noted among patients receiving human insulin therapy. Instead, the results showed an increased HbA1c level of 0.11 %, p = 0.347. Meanwhile, for analogue insulin group, a reduction of HbA1c by 0.99 % was observed, p = 0.004. A total of 13 (37.14%) incidents of hypoglycaemia reported among patients receiving human insulin. Meanwhile, 3 (8.57%) incidents of hypoglycaemia were reported in patients receiving analogue insulin. Premixed human insulins and analogue insulins might not perform similarly. Analogue insulin was associated with better HbA1c control and significantly less incidents of reported hypoglycaemia. Optimal control of postprandial blood sugar is equally important.

Keywords: Type 2 Diabetes Mellitus, Human Insulins, Analogue Insulins, HbA1c, Hypoglycaemia.