ASSESSING THE MAGNITUDE OF BLOOD PRESSURE REDUCTION IN NEWLY DIAGNOSED PATIENTS TREATED WITH PERINDOPRIL OR AMLODIPINE MONOTHERAPY AT VARIOUS DOSAGES – A RETROSPECTIVE, MULTICENTER OBSERVATIONAL STUDY
Yen Ping Ng*, Alan Ker Loon Eng, Jing Ng, Ahmad Kamal Ariffin, Boon Seng Tan, Jin Yi Choo, Yee Mei Ng and Cheng Hoon Yap
ABSTRACT
Hypertension is a well-established modifiable risk factor for the spectrum of cardiovascular diseases. What is being missing from available clinical practice guidelines in managing hypertension is the absence of the data on magnitude of reduction (%) or mean BP reduction potential of individual antihypertensive agent. The main objective of this study was to identify the magnitude of BP reduction of the two most common antihypertensive agents (perindopril and amlodipine) at various dosages used in the public primary care clinics in Malaysia. A significant reduction of mean SBP was observed after three months of treatment with perindopril 4mg OD. Mean SBP was reduced significantly by 5.47% (95% CI: 4.15-12.15, p < 0.001). However, there was no statistically significant reduction in mean DBP (p = 0.368). Amlodipine 5mg OD reduced both mean SBP and DBP significantly. Mean SBP was reduced by 8.48% after 3 months of treatments (p < 0.001) while mean DBP was reduced by 4.65% (p < 0.001). Amlodipine 10mg OD reduced mean SBP and DBP significantly. Mean SBP was reduced significantly by 9.04% (p < 0.001). Mean DBP was reduced significantly by 7.22% (p = 0.001). Mean BP reduction by perindopril 4mg OD in study population was 5.47%/1.23%. Amlodipine 5mg OD, and 10mg OD reduced mean BP in study population by, 8.48%/4.65%, and 9.04%/7.22% respectively. The result of this study shall provide the mean BP reduction of both commonly used antihypertensive agents.
Keywords: Hypertension, perindopril, amlodipine, magnitude of BP reduction, Malaysia.
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