European Journal of Biomedical and Pharmaceutical Sciences

THE PHARMACOLOGICAL ASSESSMENT OF CARISSA CARANDAS (L.) IN DIABETICS

Shikha Gautam and Prashant Kumar Singh*

ABSTRACT

Carissa carandas (L.) is investigated for its potential therapeutic role in managing diabetes mellitus, a chronic metabolic disorder characterized by hyperglycemia. This review synthesizes current research findings on the pharmacological properties of Carissa carandas relevant to diabetes treatment. The plant exhibits significant antidiabetic effects through various mechanisms, including enhancement of insulin secretion, improvement of insulin sensitivity, inhibition of carbohydrate digestive enzymes (alpha-amylase and alpha-glucosidase), and modulation of hepatic gluconeogenesis. These mechanisms collectively contribute to reducing blood glucose levels and mitigating postprandial hyperglycemia. Experimental studies have demonstrated the efficacy of Carissa carandas extracts in lowering blood glucose levels in diabetic animal models, suggesting its potential as a natural alternative or adjunct to conventional antidiabetic therapies. Further clinical trials are warranted to validate these findings and establish the safety and efficacy of Carissa carandas in human subjects. Mechanistic studies should focus on elucidating the specific molecular pathways involved in its antidiabetic effects, while efforts to standardize extracts and formulations are essential for ensuring consistency in therapeutic outcomes. In conclusion, Carissa carandas holds promise as a novel therapeutic agent for diabetes management, though further research is needed to fully understand its clinical potential and integration into diabetes treatment protocols.

Keywords: Carissa carandas, Diabetes mellitus, Antidiabetic, Glucose metabolism, Phytochemicals.