European Journal of Biomedical and Pharmaceutical Sciences

STUDIES ON THE MOLECULAR INTERACTIONS IN THE MIXTURES OF ANTIFUNGAL, PHARMACEUTICAL INTERMEDIATE AND DISINFEECTANT THROUGH DIELECTRIC PARAMETERS

A. Prathima*

ABSTRACT

The molecular interactions of the binary mixtures of anti-fungal - caprylic acid and pharmaceutical intermediate - valeric acid in disinfectant- o-cresol are studied by determining the dielectric parameters such as Kirkwood correlation factor, Excess permittivity, Bruggemann factor and Dipolar excess free energy. These parameters have been calculated from the experimentally measured values of capacitance and refractive index of mixtures, at temperatures 303K, 313K and 323K. In the above studied systems, existence of short and long range, homo and hetero interactions are identified. These interactions are found to be concentration and temperature dependent. The hetero interaction results in the formation linear as well as closed multimers in the mixture. Due to the existing interactions, structural changes are found to take place.

Keywords: candida albicans, fungal yeast, antifungal, disinfectant, pharmaceutical intermediate, caprylic acid, valeric acid.