Abstract
COMPARATIVE STUDIES OF GENERIC AND BRANDED TABLETS OF DILTIAZEM HYDROCHLORIDE

Bhavyashree T.*, Srinivasa U., Bhavyashree Naik V., Chaithanya, Chaithanya M., Chaithra, Divya and Shabaraya A. R.

ABSTRACT

Diltiazem hydrochloride is a benzothiazepine derivative calcium‐channel blocker with proven antianginal and antihypertensive capabilities. Generic drugs are identical or bioequivalent to a branded drug in dosage form, safety, strength, route of administration, quality and performance characteristic and intended use. Branded medicine is the original product that has been developed by a pharmaceutical company. The present study was to compare the generic and branded tablets of diltiazem hydrochloride by performing various tests like hardness, thickness, weight variation, drug content and dissolution rate. The selected generic tablets were coded as G1, G2 and branded tablets were coded as B1, B2. It was observed that the result obtained for branded medicines were comparatively better than the results obtained for that of generic medicines, but both the results were found to be within the permissible limits.

Keywords: Generic drugs, Branded drugs, Benzothiazepine derivative, Diltiazem hydrochloride.


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