European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND DEVELOPMENT OF SOLID LIPID NANOPARTICLES CONTAINING COUROUPITA GUIANENSIS EXTRACT

Ahamad Shahid Margoob, Dhote Vinod*, Dhote Kanika and Jain Surendra

ABSTRACT

Nanotechnology-based drug delivery systems have increasingly been developed in the last decades and have
significantly impacted the pharmaceutical sciences. They play a critical role in delivering hydrophobic drugs,
which comprise more than 40% of approved drugs. Formulation was carried out by Solvent evaporation method.
Trial batches indicated that polymers are suitable for the Nanoparticles formulation polymer produced good
formulations. Compritol and Sodium lauryl sulphate were selected for further studies. Scanning electron
micrograph of the prepared solid lipid nanoparticles at 20.00 KX magnification showed that the Nanoparticles
were smooth surface morphology and spherical shape. The porous nature of Nanoparticles was clearly observed in
the SEM images. Particle size and zeta potential was determined by Malvern Zeta sizer. The particle size analysis
confirmed that the prepared sample were in the nanometer range. Average particle size obtained for the all
formulations were 146.5 nm to 808.8 nm. Zeta potential values of Solid lipid Nanoparticles indicated that the
formulated Solid lipid Nanoparticles is stable (-03. mV to 27.5mV). This is because the newly developed Solid
lipid Nanoparticles is believed to exhibit a core shell structure with a core formed. The formulations were
optimized on the bases of results of all formulations. Effect of polymer type and extract: polymer ratio on the
evaluation parameter of formulated extract loaded solid lipid Nanoparticles on evaluation parameter was studied.
Even though the particle size of Solid lipid Nanoparticles F2 formulation is selected as the optimum formulation
due to its comparatively better result of all parameter including particle size, zeta potential, antimicrobial and SEM
etc.

Keywords: Drug delivery, Nanoparticles, Novel drug Delivery, Solid lipid nanoparticles, Couroupita Guianensis.