FORMULATION AND EVALUATION OF KETOPROFEN TABLETS BY USING NATURAL SUPERDISINTEGRANTS
*Dr. Ritesh S. Bathe, Bhagyashri R. Latare, Akash P. Punwatkar, Aachal P. Kawade and Akansha C. Dahat
ABSTRACT
The end of the present exploration is to formulate Conventional Ketoprofen tablets. Ketoprofen is a non-steroidal anti-inflammatory (NSAID) medicine with analgesic, anti-inflammatory, and antipyretic goods. It's extensively used in the treatment of inflammation and pain associated with rheumatic diseases similar as rheumatoid arthritis, osteoarthritis, and in soft towel injury. Conventional Ketoprofen tablets were prepared by using wet granulation system using natural superdisintegrants like Potato bounce, sludge bounce and Taro (Arabi) bounce. The set tablets were characterized for their hardness, frangibility, weight variation, decomposition time and in vitro dissolution studies. The capability of the tablet to release the medicine briskly depends on the attention and type of superdisintegrants. In this study the conventional tablets containing Potato bounce, sludge bounce and Taro (Arabi) bounce used as the superdisintegrants in the rate of 111. Where the F3 shows better released of medicine. About75.81 of the medicine was released from the tablets in 3 hour. Thus, grounded on the evaluation parameters, in vitro medicine release profile of F3 expression containing Taro (Arabi) bounce is optimized as the stylish expression with high decomposition rate. Keywords Conventional Tablets, Rheumatoid arthritis, Osteoarthritis, Superdisintegrants, Ketoprofen, Corn bounce, Taro bounce, in vitro evaluation.
Keywords: Conventional Tablets, Rheumatoid arthritis, Osteoarthritis, Superdisintegrants, Ketoprofen, Corn starch, Taro starch, in vitro evaluation.
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