THE PRESENT AND FUTURE PERSPECTIVES IN GASTRO RETENTIVE DRUG DELIVERY SYSTEMS (GRDDS)
Sante Rohini U.*, Fugate Ajay, Punam Londhe and Swati Jadhav
ABSTRACT
One novel approach in this area is GRDDS (Gastro Retentive Drug Delivery System). Gastroretentive drug
delivery systems (GRDDs) are designed to prolong the residence time of a drug in the stomach. This can be
beneficial for drugs that are destroyed by stomach acid or that need to be delivered in a sustained-release manner.
GRDDs are a promising new technology for improving the delivery of drugs to the gastrointestinal tract. They
have the potential to improve the efficacy and safety of drugs, and to reduce the number of side effects. In recent
decades, many efforts have been made in order to improve drug bioavailability after oral administration.
Gastroretentive drug delivery systems are a good example; they emerged to enhance the bioavailability and
effectiveness of drugs with a narrow absorption window in the upper gastrointestinal tract and/or to promote local
activity in the stomach and duodenum. Several strategies are used to increase the gastric residence time, namely
bio adhesive or mucoadhesive systems, expandable systems, high-density systems, floating systems, super porous
hydrogels and magnetic systems. The frequency of drug administration depends on its half-life, or means
residence time (MRT), and its therapeutic index. GRDDs are a promising new technology for improving the
delivery of drugs to the gastrointestinal tract. They have the potential to improve the efficacy and safety of drugs,
and to reduce the number of side effects.
Keywords: Gastro retentive drug delivery system (GRDDs); CR; Conventional Drug Dosage Form; Bioavailability; Gastric Retention Time, Narrow absorption window, Raft forming system.
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