European Journal of Biomedical and Pharmaceutical Sciences

PHARMACOLOGICAL EFFECT OF ALANGIUM SALVIFOLIUM ON HIGH FAT DIET INDUCED HYPERLIPIDEMIA IN RATS

Manoj Kumar*, Dr. Ahmad, Ashok Kumar and Ashok Kumar Yadav

ABSTRACT

Hyperlipidemia, characterized by elevated levels of cholesterol and triglycerides coupled with decreased HDL cholesterol, is a significant lipid metabolism disorder associated with increased risk of cardiovascular diseases. In this preclinical study, we evaluated the anti-hyperlipidemic effects of Alangium salvifolium, a plant traditionally used in folk medicine, using a rat model with high-fat diet (HFD)-induced hyperlipidemia. The study involved administering oral extracts of Alangium salvifolium at doses of 200 mg/kg and 400 mg/kg. Results indicated a significant reduction in serum lipid levels (P < 0.05) in treated rats compared to the control group. While the HFD initially caused a marked decrease in HDL cholesterol, treatment with Alangium salvifolium led to a notable increase in HDL levels. The reduction in serum cholesterol and triglycerides, along with the increase in HDL cholesterol, supports the traditional use of Alangium salvifolium as a therapeutic agent for managing hyperlipidemia. This study not only underscores the plant's efficacy in improving lipid profiles but also highlights its potential as a natural alternative in the treatment of hyperlipidemia. Further research is warranted to explore the mechanisms underlying these effects and to evaluate the long-term benefits and safety of Alangium salvifolium in lipid metabolism disorders.

Keywords: Hyperlipidemia, Alangium salvifolium, Cholesterol, Triglycerides, HDL cholesterol.