PHARMACEUTICAL NANOSUSPENSION: UNVEILING THE SYNERGY OF BOTTOM –UP AND TOP-DOWN FORMULATION STRATEGIES: A REVIEW
Komal P. Shinde* and Abhay T. Sangamwar
ABSTRACT
Nanotechnology is the science that studies the process that occurs at molecular level and of nano length scale size. Nano refers to the particle size range of 1-1000 nm. Nanosuspensions are belongs to nanotechnology. A Drug nanosuspension is defined as perfectly colloidal, biphasic drug substances, dispersed solid drug particles in an aqueous vehicle, size of less than 1 μm stabilized by surfactants and polymers prepared by suitable methods for drug delivery applications. It ensures efficient delivery of hydrophobic drugs and increases the bioavailability. It is an attractive and promising tool to improve poor solubility and bioavailability of the drugs. It increase medication stability and can be easily prepared for water- insoluble drugs using techniques such as high- pressure homogenizers, wet mills and emulsion solvent evaporation. Additives like stabilizers, solvents, buffers, salts, and cryoprotectants can be used for this. Nanosuspensions can be administered orally, parenterally, intravenously, and can be combined with ocular inserts and mucoadhesive hydrogels for targeted drug delivery. This article describes the preparation of nanosuspensions and their application in pharmaceutical research.
Keywords: Nanotechnology, Nanosuspensions, polymers, drugs. Bottom-up Technology, Top- Down Technology etc.
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