European Journal of Biomedical and Pharmaceutical Sciences

EFFECTS OF PREBIOTIC SUPPLEMENTATION ON LACTOSE INTOLERANCE AND LACTOSE MAL-DIGESTION: A SYSTEMATIC REVIEW OF INULIN-TYPE FRUCTANS UTILIZATION BY LACTIC ACID BACTERIA AND PROMOTES GUT HEALTH

Padmavathi Vijayakumar*, Venkatesh Babu Murugesan and Gomathi Mohan

ABSTRACT

Milk and dairy products are considering an important human diet which accelerates normal physiological growth
and development in mammalian. However, the consumption of these diet not made possible to tolerate by every
individual especially in adulthood. Lactose intolerance (or) lactose mal-digestion is a metabolic disorder,
affects approximately 75% of the world population. In this condition, the expression of lactase in the brush
border of the small intestine is reduced. Lactase is a hydrolytic enzyme which cleaves the sugar lactose found in
the milk and dairy products into glucose and galactose in the small intestine. The mal-digestion of lactose results in
the clinical symptoms include abdominal pain, bloating, cramps, flatulence, diarrhea, constipation, nausea, and
vomiting. Several studies demonstrated that probiotics administration could alleviate in the gastrointestinal
symptoms but some strains are sensitive to gastric environment and bile condition of our body and also still it is
having challenges. Prebiotics are dietary fibers which shows promising results in lactose intolerance. Fructooligosaccharides
(FOS) especially inulin-based supplements could alleviate the symptoms of lactose maldigestion
as well as they stimulate the intestinal microbial flora and encouraging their growth. This study to
discuss about inulin based supplements could modify the mechanisms of microbiota and alleviate the symptoms of
lactose intolerance and helps to recover from gastrointestinal disorders including lactose intolerance. Even we
discuss, formulate Inulin-type Fructans, which is derived from the dandelion roots as prebiotic supplements which
plays a decisive role in the stimulation and growth of beneficial gut- microbiota as well as gut health.

Keywords: Lactose intolerance, Fructo-oligosaccharides, Inulin, Microbial gut flora and dairy products.