RATIONAL DRUG UTILIZATION STUDY ON FIXED DOSE COMBINATIONS OF ANTIBIOTICS IN A TERTIARY CARE HOSPITAL
Khwaja Amtul Raouf Qazi and N. Anitha*
ABSTRACT
Aim: To study the prescribing pattern and to assess the rationality of fixed dose combinations of antibiotics in various Department & General wards of a tertiary care hospital. Methods: A cross-sectional prospective study was carried out in four inpatients departments (Surgery, Orthopaedics, ENT, Obstetrics & Gynaecology) along with General Ward of a 550-bedded tertiary care hospital. Total 125 inpatients data from all departments were evaluated for prescribing pattern of fixed dose combinations of antibiotics. Data were also assessed for demographic information like number of single formulations of antibiotics used & fixed dose combinations other than antibiotics. Results: Among four departments, FDCs were prescribed as the highest percentage in the ENT department. Amoxicillin+Clavulanic acid was the most common prescribed FDC in ENT and Surgery department. Obstetrics & Gynaecology department had maximum percentage of prescription of Clotrimazole + Tinidazole + Clindamycin. Cefoperazone+Sulbactam FDCs was maximally prescribed in surgery, Obstetrics & Gynaecology and Orthopaedics departments. Diclofenac+Paracetamol and Folic acid combinations were the most commonly prescribed FDC’s other than antimicrobials in ENT, Obstetrics & Gynaecology and Surgery. Conclusion: It was observed that the hospital physicians prescribed antibiotics more rationally with no banned drugs and very few new drugs. This study will highlight on assessing the rationality of fixed dose combination which will aware healthcare professional which ultimately decrease the adverse effects.
Keywords: Fixed Dose Combination, Rational Drug use, Antibiotics.
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