STRUCTURAL, SPECTRAL AND ANTIMICROBIAL STUDIES OF COPPER(II) COMPLEX OF PYRROLIDIN-2-YLIDENE-2,(4-CHLOROPHENYL) SEMICARBAZONE
Achonye C. C.*, Ezenweke L. O., Ojiako E. N. and Ogbuagu O. E.
ABSTRACT
Pyrrolidin-2-ylidene-2,(4-chlorophenyl)semicarbazone and its copper (II) complex were synthesized with aim to elucidating their structures and determining their antimicrobial activities. Melting point, magnetic susceptibility, conductivity measurement, XRD, GC-MS, UV-Vis., IR. Spectroscopic studies were used to characterize and propose structures of the synthesized compounds. Copper (II) complex showed effective magnetic moment of 1.83BM at room temperature. The ligand and its copper (II) complex are trigonal crystals with space groups of p3121 and p3112 and respective cell volumes of 130.907 and 701.505Å3. GC-MS results revealed respective m/z values of 256.2 and 429.1 for the ligand and the complex. The ligand and its copper (II) were tested in vitro antibacterial activities against S. aureus, E. coli, K. pneumonia, B. subtilis and for antifungal activities againt A. flavus and C. albicans. Among organisms tested, copper (II) complex of the ligand proved to be a more potent antibacterial agent against E. coli, K. pneumonia and B. subtilis. The complex exhibited better antimicrobial activity than the free ligand.
Keywords: Phenylsemicarbazone, pyrrolidone moiety, Metal complexes, Anti-bacterial activities, Anti-fungal activities.
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