Abstract
A CONVENIENT SYNTHESIS AND ANTI-FUNGAL ACTIVITIES OF NEW IMIDAZO[1,2-A]-S-PYRIMIDIN-7-ONES

Manoj Kumar Srivastava* and Anamika Pandey

ABSTRACT

Michael addition of nitrogen nucleophiles, 2-(arylamino)imidazolidines 3a-e to 4– Arylidine-5(4H)oxazolones 4a-e followed by ring transformation of the isolable Michael adducts 5a-l yields new bicyclic compounds 5,8-diaryl-6-benzamido-2,3,5,6-tetrahydro-7H-imidazo[1,2-a]pyrimidin-7-ones 6a-l in one pot procedure. The formation of Michael adducts 5a-l and their ring transformation to 6a-l are highly diastereoselective. Compounds 6e-f exhibit 100% in vitro disease control (equivalent to Dithane M-45) against Aspergillus niger and Fusarium oxysporum at 1000 ppm concentration.

Keywords: Imidazolidines, Diastereoselective, oxazolones, Aspergillus niger, Fusarium oxysporum, Pyrimidines


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