HEALING POTENTIALS OF ANNONA MURICATA LEAVES EXTRACT AGAINST HYOSCINE INDUCED OXIDATIVE STRESSED WISTA RATS AND ITS EFFECT ON LIVER ENZYMES
Emmanuel Nonso Ezeokafor, Winifred Chioma Ezekwudo, Kosisochukwu Emmanuel Ifemenam*, Serah
Wuraola, Njideka Constance Uchefuna, Ike chibueze Jeremiah, Sebastine Okechukwu Nwoko, Cordelia U. Nsofor, Sebastine Okechukwu Nwoko, Paul Chinwuba and Chiemelia Ujunwa Anisiobi
ABSTRACT
Annona muricata is a plant that has several medicinal properties; however, there are dearths of scientific
information on the healing activities. This study therefore focused on the healing effects of the methanolic leaves
extract of A. muricata against Hyoscine induced oxidative stress and liver morphology in Wister rats. Twenty five
rats divided into five research subgroups were used for this study. Group A was the control group Group B
received Hyoscine only while Groups C,D and E received 1ml/kg of Hyoscine and 0.15, 0.30 and 0.65ml/kg of
MAM respectively. The result revealed a significant decrease of SOD in Groups B when compared to the control
group, while groups C-E had a significant increase when compared to group A. Also there was a significant
increase in the MDA in Group B when compared to A while groups C-E had a significant decrease when
compared to group B. Lastly there was a significant decrease in GSH in group B when compared to control group
while a significant decrease in group C-E when compared to group B. The results, therefore, sour sop is
antioxidants plants that can be used to treat oxidative stress in the female Wister rats.
Keywords: Methanolic Annona muricata, Hyoscine, Oxidative Stress.
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