European Journal of Biomedical and Pharmaceutical Sciences

SOLUBILITY ENHANCEMENT TECHNIQUES

Jaypalbhai Chauhan*, Divya Gupta, Chainesh Shah and Umesh Upadhyay

ABSTRACT

The ability of a solid to dissolve in a liquid phase and produce a uniform molecular dispersion is known as
solubility, and it is crucial to the effectiveness of drugs. However, most active pharmaceutical ingredients are
hydrophobic and poorly soluble in water. The solubility of the medicine can be one of the hardest things to work
with when creating a formulation. Important compounds with poor aqueous solubility never make it to the final
pharmaceuticals because their full therapeutic range and potential are not realized. Therefore, despite their
potential for pharmacokinetic activity, many new drugs' poor water solubility is a major barrier to their successful
market launch. If a molecule's solubility in water limits its bioavailability, then it would not be possible to develop
molecules that would have a highly beneficial effect on their physiological target.

Keywords: Solubility, bioavailability, pharmacokinetic activity, physiological target.