ASPROSIN LEVELS AFTER SLEEVE GASTRECTOMY IN A RAT MODEL OF DIABETES MELLITES TYPE 2
Dr. Mohamad Yosof and Dr. Rania Refeat
ABSTRACT
Background: Asprosin is a novel glucokine produced mainly by the white adipose tissue. Many studies
investigated the role of asprosin in diabetes type-2 and confirmed the relationship of asprosin to body weight.
Aim: According to available resources, no data demonstrating the effect of sleeve gastrectomy on serum asprosin,
so the aim of this study was to demonstrate this effect and search the timing of this effect after sleeve gastrectomy
in an experimental model for type 2, diabetes. Materials and Methods: 40 adult male albino rats were divided
into four groups; (10 rats each); 1st: Control (C) group, 2nd: Diabetic (D) rats, 3rd: Diabetic Sham operated (SO),
and 4th: Diabetic with Sleeve gastrectomy (DSG). Body weight, food intake, blood glucose, serum asprosin,
Insulin, HOMA-IR and HOMA-B were measured. Results: asprosin level was significantly increased in diabetic
group (19.03 ± 2.5) compared with the control group (14.05 ± 1.2). Asprosin is significantly decreased in diabetic
with sleeve gastrectomy group (17.23 ± 2.6) compared with the diabetic group (18.07 ± 2.4) and this reduction is
higher 6 weeks and highest 14 weeks after sleeve gastrectomy (15.03 ± 3.5, 14.06 ± 1.1 respectively) compared
with diabetic group (39.05 ± 5.7, 53.03 ± 6.5 respectively). Asprosin is positively correlated with the body mass
index (P-Value is < .00001). Conclusion: Asprosin is significantly reduced after sleeve gastrectomy and this
reduction is time related. Asprosin has a potential therapeutic role in weight reduction.
Keywords: .
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